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EARLY INTERVENTION CAN MAKE A DIFFERENCE2,8,9

By identifying patients and intervening early, you can help slow the progression of kidney disease, reduce the risk of cardiovascular disease, and delay the need for dialysis.2,8,9

 

 

EARLY INTERVENTION CAN SLOW DISEASE PROGRESSION IN CKD PATIENTS2,4

CKD progression with and without early intervention
CKD progression with and without early intervention

WHEN CKD PROGRESSES, THE RISK OF ADVERSE OUTCOMES INCREASES10*

Age standardized rate of hospitalization
Age standardized rate of hospitalization
Age standardized rate of HF and CV events
Age standardized rate of HF and CV events
Age standardized rate of death from any cause
Age standardized rate of death from any cause

Adapted from Go AS et al, 2004.

*Study design: Analysis of data from a US Renal Registry (1,120,295 adults, 20 years or older with at least 1 outpatient determination of serum creatinine levels recorded between January 1996 and December 2000), to examine the multivariable association between the estimated GFR and the risks of death, CV events and hospitalisation. Subjects who had already received a kidney transplant or receiving maintenance dialysis at entry were excluded.10

NEXT: Know Your Patients’ Numbers

CKD = chronic kidney disease; CV = cardiovascular; eGFR = estimated glomerular filtration rate; GFR = glomerular filtration rate; UACR = urine albumin - to - creatinine ratio.

References

  1. Kidney Health Australia. Evidence Report 2021. Make the Link Kidneys, Diabetes & Heart. Accessed March 2023. Available at: https://kidney.org.au/uploads/resources/KHA-Report-Make-the-link-kidneys-diabetes-heart.pdf
  2. Ravera M et al. Am J Kidney Dis. 2011;57(1):71-77.
  3. GBD Chronic Kidney Disease Collaboration. Lancet. 2020;395(10225):709-733.
  4. Kidney Health Australia. Chronic Kidney Disease (CKD) Management in Primary Care. 4th Edition (2020). Accessed August 2022. Available at: https://kidney.org.au/uploads/resources/CKD-Management-in-Primary-Care_handbook_2020.1_2021-05-14-070433.pdf
  5. Larmour K et al. Clin J Am Soc Nephrol. 2021;16(7):1117-1119.
  6. Australian Bureau of Statistics. Australian Health Survey: Biomedical Results for Chronic Diseases. Accessed April 2023. Available at: https://www.abs.gov.au/statistics/health/health-conditions-and-risks/australian-health-survey-biomedical-results-chronic-diseases/latest-release#chronic-kidney-disease
  7. Kidney Health Australia, Algorithm for initial detection of CKD. Accessed August 2022. Available at: Algorithm-for-initial-detection-of-CKD_2021_logo.pdf (kidney.org.au)
  8. Ryan TP et al. Am J Med. 2007;120(11):981-986.
  9. Kidney Disease: The Basics. National Kidney Foundation. Published May 2020. Accessed July 2021. Available at: https://www.kidney.org/news/newsroom/factsheets/KidneyDiseaseBasics
  10. Go AS et al. N Engl J Med. 2004;351(13):1296-1305.
  11. Estimated glomerular filtration rate (eGFR). National Kidney Foundation. Reviewed 14 September 2020. Accessed July 2021. Available at: https://www.kidney.org/atoz/content/gfr
  12. Kidney Health Australia. Stages of kidney disease. Accessed July 2021. Available at: https://kidney.org.au/your-kidneys/what-is-kidney-disease/stages-of-kidney-disease
  13. Kidney Disease: Improving Global Outcomes (KDIGO). KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. 2013;3(1):1-150. Accessed March 2023. Available at: https://kdigo.org/wpcontent/uploads/2017/02/KDIGO_2012_CKD_GL.pdf
  14. Ghaderian SB et al. J Renal Inj Prev. 2014;3(4)109-110.
  15. Courser WG et al. Kidney Int. 2011;80(12):1258-1270.
  16. Kidney Disease Stats. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. December 2016. Accessed July 2021. Available at: https://www.niddk.nih.gov/health-information/health-statistics/kidney-disease
  17. Yacoub R et al. BMC Public Health. 2010;10:731.
  18. Schnaper HW. Pediatr Nephrol. 2014;29(2):193-202.
  19. Chagnac A et al. Nephron. 2019;143(1):38-42.
  20. Cravedi P et al. Br J Clin Pharmacol. 2013;76(4):516-523.
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