This site is intended for Australian healthcare professionals.

UNDERLYING MECHANISM OF CKD

INSIDE THE KIDNEYS,
PRESSURE IS BUILDING

Inside kidneyInside kidneyLOOK INSIDE

INSIDE THE KIDNEYS,
PRESSURE IS BUILDING

Inside the kidneys,
pressure is building

While patients may experience no early symptoms of CKD, inside their kidneys, intraglomerular pressure is building.2,18

As intraglomerular pressure builds, it slowly destroys nephrons, leading to progressive damage and reduced kidney function.18,19,20

Inside the kidneys,
pressure is building

While patients may experience no early symptoms of CKD, inside their kidneys, intraglomerular pressure is building.2,18

As intraglomerular pressure builds, it slowly destroys nephrons, leading to progressive damage and reduced kidney function.18,19,20

NEXT: Resources for You and Your Patients

CKD = chronic kidney disease; CV = cardiovascular; eGFR = estimated glomerular filtration rate; GFR = glomerular filtration rate; UACR = urine albumin - to - creatinine ratio.

References

  1. Kidney Health Australia. Evidence Report 2021. Make the Link Kidneys, Diabetes & Heart. Accessed March 2023. Available at: https://kidney.org.au/uploads/resources/KHA-Report-Make-the-link-kidneys-diabetes-heart.pdf
  2. Ravera M et al. Am J Kidney Dis. 2011;57(1):71-77.
  3. GBD Chronic Kidney Disease Collaboration. Lancet. 2020;395(10225):709-733.
  4. Kidney Health Australia. Chronic Kidney Disease (CKD) Management in Primary Care. 4th Edition (2020). Accessed August 2022. Available at: https://kidney.org.au/uploads/resources/CKD-Management-in-Primary-Care_handbook_2020.1_2021-05-14-070433.pdf
  5. Larmour K et al. Clin J Am Soc Nephrol. 2021;16(7):1117-1119.
  6. Australian Bureau of Statistics. Australian Health Survey: Biomedical Results for Chronic Diseases. Accessed April 2023. Available at: https://www.abs.gov.au/statistics/health/health-conditions-and-risks/australian-health-survey-biomedical-results-chronic-diseases/latest-release#chronic-kidney-disease
  7. Kidney Health Australia, Algorithm for initial detection of CKD. Accessed August 2022. Available at: Algorithm-for-initial-detection-of-CKD_2021_logo.pdf (kidney.org.au)
  8. Ryan TP et al. Am J Med. 2007;120(11):981-986.
  9. Kidney Disease: The Basics. National Kidney Foundation. Published May 2020. Accessed July 2021. Available at: https://www.kidney.org/news/newsroom/factsheets/KidneyDiseaseBasics
  10. Go AS et al. N Engl J Med. 2004;351(13):1296-1305.
  11. Estimated glomerular filtration rate (eGFR). National Kidney Foundation. Reviewed 14 September 2020. Accessed July 2021. Available at: https://www.kidney.org/atoz/content/gfr
  12. Kidney Health Australia. Stages of kidney disease. Accessed July 2021. Available at: https://kidney.org.au/your-kidneys/what-is-kidney-disease/stages-of-kidney-disease
  13. Kidney Disease: Improving Global Outcomes (KDIGO). KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. 2013;3(1):1-150. Accessed March 2023. Available at: https://kdigo.org/wpcontent/uploads/2017/02/KDIGO_2012_CKD_GL.pdf
  14. Ghaderian SB et al. J Renal Inj Prev. 2014;3(4)109-110.
  15. Courser WG et al. Kidney Int. 2011;80(12):1258-1270.
  16. Kidney Disease Stats. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. December 2016. Accessed July 2021. Available at: https://www.niddk.nih.gov/health-information/health-statistics/kidney-disease
  17. Yacoub R et al. BMC Public Health. 2010;10:731.
  18. Schnaper HW. Pediatr Nephrol. 2014;29(2):193-202.
  19. Chagnac A et al. Nephron. 2019;143(1):38-42.
  20. Cravedi P et al. Br J Clin Pharmacol. 2013;76(4):516-523.
Back to top